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Experimental observations indicate that the combination allows investigation of complementary pathways in tissue regeneration, including vascular growth, fibroblast recruitment, matrix reorganization, and oxidative stress responses

Additionally, mast cells directly respond to gliadin fragments (part of the gluten protein) and release proinflammatory mediators.[ref] Related article: Celiac Genes Ehlers-Danlos, Hypermobility, and Mast Cell Activation: As mentioned above, mature mast cells are found in tissues and congregate in the connective tissue around lymphatic vessels, blood vessels, nerves, and skin