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Homocysteine level is a more direct measure of the function of vitamin B12 and folic acid (compared to red blood cell or serum testing)

The skin after scraping off the characteristic scales is smooth and shiny

The transdermal composition of claim 2 wherein polymer is selected from one or more of polyethylene glycol, methacrylate copolymers (Eudragits), Acrylic copolymer, Polyster Film/copolymer of ethylene and vinyl acetate, Poly (Butyl methacrylate, methyl methacrylate), cellulose polymers (carboxymethylcellulose, ethyl cellulose, hydroxypropylmethylcellulose hydroxypropylcellulose), polyvinylpyrrolidone, polymer of acrylic acid crosslinked with allyl ethers of polyalcohols (carbomer / carbopol)

Of these, SREBP-1c is predominantly expressed in the liver, where it governs TG synthesis, whereas SREBP-2 is ubiquitously distributed and regulates 3-hydroxy-3-methylglutaryl-coenzyme A reductase, the rate-limiting enzyme in cholesterol biosynthesis (Li et al