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A unifying feature is their ability to mitigate oxidative stressfor example, many flavonoids, alkaloids, and saponins activate the Nrf2/ARE pathway, upregulating endogenous antioxidant enzymes (such as superoxide dismutase and glutathione peroxidase) to neutralize excess reactive oxygen species (Wang Q

Consider that ethanol upregulates CYP enzymes, which will increase the metabolism of acetaminophen, leading to a shorter duration of action and increased production of the toxic metabolite NAPQI

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Upon binding it increases the AMP/ATP ratio increasing the glucose uptake in the skeletal muscles