PMCID: PMC7073937
Heartburn or acid reflux Chest pain or discomfort Difficulty swallowing Regurgitation of food or liquids Shortness of breath Bloating or burping after meals Several factors may contribute to the development: Age-related weakening of the diaphragm Chronic coughing or straining during bowel movements Injury or trauma to the abdominal area Increased pressure in the abdomen (due to obesity, pregnancy, or heavy lifting) Sliding Hiatal Hernia Most common type, where the stomach and esophagus slide in and out of the chest through the hiatus
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A method for preventing radiation-induced ototoxicity in an individual in need thereof comprising intratympanic administration of a pharmaceutical composition comprising a therapeutic agent selected from a JNK inhibitor, TRPV modulator, an MET channel inhibitor, and an otoprotectant to the individual in need thereof, wherein the pharmaceutical composition is administered prior to onset of radiation therapy, and wherein the composition provides sustained release of the therapeutic agent into the ear for a period of at least 5 days after a single administration