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Further mechanistic investigations determined that the elevation of intracellular GSSG levels resulted in NF-B inhibition by facilitating glutathionylated IKK- (IKK--SSG) formation, leading to enhanced TNF hepatotoxicity

Similarly, other ligands (triphenylphosphonium, AS1) and gH625 (viral derived peptide for effective delivery) have already been shown to preferentially target astrocytes (79)

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It has less muscle wasting, much better safety profile, lower side effect profile, but people drop substantial amounts of body fat