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In patients with seropositive RA (that is, characterized by the presence of autoantibodies) evidence is accumulating that immunity against post-translationally modified (such as citrullinated) autoantigens might be triggered in mucosal organs, such as the lung, long before the first signs of inflammation are seen in the joints

In the future, priority should be given to advancing clinical trials, optimizing injectable formulations and administration regimens, addressing environmental and cost issues in production, and strengthening synergistic research with other preparations to enhance its application value and promote the leap from scientific research to clinical practice

While we have been overwhelmed with inquiries, we would like to note that our current knowledge is limited to the details provided in the linked article

Arthur JR (2000) The glutathione peroxidases