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Cecal levels of Akkermansia muciniphila have been strongly correlated with physiological metrics including glycemia and insulinemia 89 , and Akkermansia has correlated negatively with obesity-related measures 90 and has been implicated in DIO prevention 91,92

Neuroendocrine normalization: Studies in aged animal models document normalized anterior pituitary function and restored luteinizing hormone and follicle-stimulating hormone pulsatility following administration