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Natural sulfur compounds such as GSH, SFN, taurine, allyl sulfide, sulfated polysaccharides, and cysteine and methionine having roles in modulating histone deacetylases, DNA methyltransferases, and modulating SAMe expression are also emerging as potential interventions under these conditions besides its major role in anti-inflammatory and oxidative stress

It functions as both a GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) receptor agonist

Histological studies have demonstrated disorganization of collagen fiber alignment, increased vascularity, mucoid degeneration, and loss of fibroblast density (Table 1) (Nyland et al., 2020)