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Like the Chorein_N-domian-containing protein VPS13, which transfers phospholipids between the ER and other organelles (Kumar et al, 2018), ATG2 protein forms a long hydrophobic groove where the fatty acid chains of phospholipids can be accommodated, enabling ATG2 to transport phospholipids from the ER to phagophores for their expansion (Osawa et al, 2019

Calreticulin and PDI, in particular, have been associated with the misfolded protein accumulation in the ER and oxidative stress [60]

Common reconstitution volumes: 20mg vial + 2mL BAC water = 10mg/mL concentration 40mg vial + 2mL BAC water = 20mg/mL concentration 40mg vial + 3mL BAC water = 13mg/mL concentration Add diluent slowly: Insert the needle into the vial at an angle and allow the water to flow down the inside wall of the vial

Targeting ETC CI enhances 5FU response and extends survival The ultimate goal of better understanding mechanisms promoting 5FU tolerance is to allow us to design rational treatment combinations that are more effective than the current standard of care