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[44] In the cytosol [edit] Methylcobalamin and 5-methyltetrahydrofolate are needed by methionine synthase in the methionine cycle to transfer a methyl group from 5-methyltetrahydrofolate to homocysteine, thereby generating tetrahydrofolate (THF) and methionine, which is used to make SAMe

A smaller group feels briefly worse first: tired, achy, headachy or off-colour for a day or two

However, definitive comparative dosage studies are still emerging in 2026

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