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Moreover, SLNs address limitations of Rif, such as solubility and absorption, by enhancing its stability and permeability in intracellular environments [153]

In addition to their carbohydrate composition, the protein content in dates (23% approximately) makes them a source of essential amino acids such as lysine, leucine, valine, and threonine [11]

Lysophosphatidylcholine acyltransferase-3 (LPCAT3) and acyl-CoA synthetase long chain family member 4 (ACSL4) are the crucial enzymes regulating PUFAs biosynthesis and remodeling by catalyzing AA to phospholipid (PL) hydroperoxide (PL-OOH, such as AA-OOH), which are considered specific biomarkers and drivers of ferroptosis (Xu et al., 2020

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