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(II) the potential role of amino acid metabolites (e.g., -ketoglutarate) in regulating iron-related gene expression through epigenetic modifications

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Japan Patent JP5634051 (B2) Taskin M (2013) A new strategy for improved glutathione production from Saccharomyces cerevisiae : use of cysteine- and glycine-rich chicken feather protein hydrolysate as a new cheap substrate

Since the hallmark of SCD is chronic hemolysis with excess hemin producing significant levels of oxidative stress, we speculate that hemin may modulate TSS pathway function