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The current study also shows links between those processes and secondhand smoke

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A study using an animal model exposed to THS under conditions that mimic exposure of humans suggests there are adverse effects of THS on liver, lung, skin healing, and behavior.In this study, THS delayed wound healing, increased hyperactivity on behavior tests, increased non-alcoholic fatty liver disease predisposing cirrhosis and cancer in liver, and stimulated excess collagen and cytokines production in lungs emulating inflammation-induced diseases such as COPD or asthma

According to the authors of the study this probably contributed to the reduction in smoking prevalence among women from less advantaged social backgrounds and encouraged those who did not quit to switch to hand-rolled products as a way to afford to continue to smoke