Depending on the strength of the peel and skin type, multiple sessions might be needed to achieve the desired results
However, the clinical evidence for vitamin C alone as a melasma treatment is modest

Yet, instead of looking at folate and B12 levels in the blood, doctors often prescribe all sorts of psychiatric medications that have been shown to deplete folate and B12, including: Antidepressants Fluoxetine (Prozac), Paroxetine (Paxil), Sertraline (Zoloft), Citalopram (Celexa), Escitalopram (Lexapro), Bupropion (Wellbutrin), Mirtazapine (Remeron), Venlafaxine (Effexor), Amitriptyline (Elavil), Doxepin (Adapin), Imipramine (Tofranil), Desipramine (Norpramin), Nortriptyline (Aventyl), Protriptyline (Vivactil) Benzodiazepines Diazepam (Valium), clorazepate (Tranxene), lorazepam (Ativan), Clonazepam (Klonopin), Alprazolam (Xanax) Antipsychotics including Aripiprazole (Abilify), Quetiapine (Seroquel), Risperidone (Risperdal), Olanzapine (Zyrexa), Haloperidol (Haldol), Paliperidone (Invega), Ziprasidone (Geodon) Anticonvulsants and Mood Stabilizers , including Lithium (Lithobid), Phenytoin (Dilantin), carbamazepine (Tegretol), Primidone (Mysoline), Methsuxamide (Elontin), Valproic acid (Depakote), topiramate (Topomax) and Gabapentin (Neurontin) B12 and folate deficiency can lead to an inability to methylate properly and increased homocysteine levels

Western diets are chock full of processed seed oils that are very high in omega-6 which can promote pro-inflammatory proteins that can weaken the immune response