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They're cellular-level failures

Cats treated with Bexacat may be at an increased risk for conditions called diabetic ketoacidosis or euglycemic diabetic ketoacidosis, both of which may result in death

Q J Med 2011

It has been suggested that the NADPH oxidases, which are responsible for ROS generation, could be major players in synucleinopathies ( DJ-1 is another gene reported to cause a familial early onset PD (Puschmann, 2013)