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no human data Animal teratogen No human data Considered safe Give folate 2 mg daily Use if mothers health mandates Contraindicated: teratogenic Possible teratogen Human data: low risk Human data: low risk Limited human data: potential toxicity No human data Human data: probably compatible No human data: probably compatible Limited human data: potential diarrhea Contraindicated Limited human data: potential toxicity No human data Limited human data: potential diarrhea No human data: possible toxicity No human data: probably compatible Limited human data: potential diarrhea Limited human data: potential toxicity No human data: potential toxicity Limited human data: probably compatible Limited human data: probably compatible Limited human data: probably compatible Abbreviation: FDA, US Food and Drug Administration

Kinase-substrate relationships were obtained from the PhosphoSitePlus database and provided as gene sets (PhosphoSitePlus)

GPs can prescribe B12 injections following appropriate investigation, which should include: Full blood count to identify macrocytic anaemia Serum B12 and folate levels to confirm deficiency (using laboratory-specific reference ranges) Methylmalonic acid and/or homocysteine when B12 results are borderline Intrinsic factor antibodies if pernicious anaemia is suspected Additional tests depending on clinical presentation (e.g., thyroid function, coeliac serology) When both B12 and folate deficiency are present, B12 should be replaced before folate to avoid precipitating subacute combined degeneration of the spinal cord

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