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In particular, MPTP intoxication typically downregulates key autophagy regulators (LC3-II, beclin-1, parkin, PINK1), but schisandrin A treatment partially preserved the levels of these proteins, implying that it enhances autophagic clearance of toxic aggregates (59, 60)

Dynamic data was first fit into kinetic models with T 1 as an unknown parameter to estimate apparent in vivo T 1 of VitC, which was subsequently incorporated into the kinetic model as a fixed parameter to generate k assuming T 1 is the same across the subjects

doi: 10.1136/gutjnl-2021-325428 92 NeurathMFArtisDBeckerC