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Furthermore, patient information and sample handling procedures should be as detailed as possible as concomitant disease, systemic inflammation, infections and medication intake as well as post-mortem tissue preparation/fixation and storage protocols could affect results and subsequent interpretation of findings (Gomez-Nicola and Boche, 2015)

The BBB in neurodegenerative diseases The BBB in Alzheimer's disease Primary pathological features of Alzheimer's disease include extracellular senile plaques composed of amyloid beta (A) fibers and intracellular neurofibrillary tangles formed by tau proteins[40]

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