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doi: 10.1074/jbc.M113.454538 130 Lussey-LepoutreCHollinsheadKELudwigCMenaraMMorinACastro-VegaLJet al

During the process of renal injury, in addition to the classical abnormal regulation of iron metabolism and lipid peroxidation, a growing number of novel metabolic pathways have also been uncovered in ferroptosis, such as the system Xc - /glutathione peroxidase 4 (GPX4) system, ferroptosis suppressor protein 1 (FSP1)/ubiquinol (CoQ10) system, dihydroorotate dehydrogenase (DHODH)/dihydroubiquione (CoQH 2 ) system, and GTP cyclohydrolase 1 (GCH1)/tetrahydrobiopterin (BH4)/dihydrofolate reductase (DHFR) system ( Figure 1 )

Signaling pathways in oxidative stress-induced neurodegenerative diseases: a review of phytochemical therapeutic interventions

You also notice that you gradually lose more weight even if there have been no changes to your diet