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[127] [128] Synthesis [edit] Biosynthesis [edit] Vitamin B 12 is derived from a tetrapyrrolic structural framework created by the enzymes deaminase and cosynthetase which transform aminolevulinic acid via porphobilinogen and hydroxymethylbilane to uroporphyrinogen III

4.5 Omega-3 fatty acids Omega-3 fatty acids are a physiologically significant class of polyunsaturated fatty acids owing to their anti-inflammatory, anti-apoptotic, and anti-proliferative properties that equip them with several health-promoting attributes

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Notably, the complement system and antimicrobial peptides were overrepresented in CHL bile, suggesting excessive activation of the innate immune system