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Glutathione peroxidase 4 is a predictor of diabetic kidney disease progression in type 2 diabetes mellitus

-glutamyl kinase (GK) encoded by PRO1 in eukaryotes or proB in prokaryotes, the first enzyme in proline biosynthetic pathway, catalyzes the formation of intermediate -glutamyl phosphate, which if accumulated could partially react with cysteine to generate -GC, and then Gsh2 adds glycine to -GC to form GSH

People with bipolar depression also show more oxidative protein damage measured by increased serum protein carbonyl content over and above people with mania or euthymia and healthy controls [85]

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