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257 Furthermore, NT-PGC-1 overexpression increases the mRNA expression of PPAR-associated genes and suppresses phenylephrine-induced reductions in carnitine palmitoyl transferase 2 (CPT2) and acyl-coenzyme A dehydrogenase-medium chain (Acadm) expression, thereby regulating fatty acid metabolism, increasing extracellular oxygen consumption, and decreasing lipid droplet accumulation in neonatal rat cardiomyocytes

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