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Those with pre-existing conditions such as irritable bowel syndrome (IBS), functional dyspepsia, or gastritis may be more prone to experiencing stomach upset from supplements generally, including B12 preparations

Specifically, nerve damage caused by vitamin B12 most often affects the extremities (hands and feet)

Likewise, given that the gray matter is particularly vulnerable during the primary phase [44, 63], we should note that, from day 7, the controls presented with edema and the loss of motoneurons in the gray matter, disturbances that were largely counteracted in BPC 157-treated rats (Table 2 and Fig

However, current research is constrained by uneven evidence quality, inconsistent findings due to multidimensional heterogeneity, and insufficiently clarified direct molecular targets