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When those junctions are compromised, by NSAIDs, alcohol, chronic stress, or repeated antibiotic courses, the result is a low-grade inflammatory state that shows up as bloating, systemic fatigue, food sensitivities, and immune dysregulation

The Safety and Efficacy of Low-Dose Naltrexone in the Management of Chronic Pain and Inflammation in Multiple Sclerosis, Fibromyalgia, Crohns Disease, and Other Chronic Pain Disorders Denise K Patten 1 , Bob G Schultz , Daniel J Berlau ~ Med Sci (Basel)

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NAD is a coenzyme involved in various cellular processes, including energy production and DNA repair