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Several research groups have investigated its interaction with the NO system and prostaglandin pathways in digestive tissue models

When any component fails, oral supplementation becomes far less effective, potentially requiring massive doses to achieve therapeutic blood levels

TheOffice of Dietary Supplements notes that B12 is key for energy and nerve health, making combo therapies a valuable option for some conditions

One reason is being low in a type of compound produced within the stomach called intrinsic factor (a type of glycoprotein), which combines with vitamin B12 once consumed in order to allow it to be absorbed