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PET imaging allows for a direct measurement of synapses in the living human brain using the radioligand [ 11 C]UCB-J, that binds to the synaptic vesicle protein 2A (SV2A), a protein that is expressed ubiquitously on synaptic vesicles throughout the brain and acts as a marker of synaptic density [240]

eLife 3 , e03596 (2014)

It effectively sequesters unbound copper from amyloid-beta complexes, reducing metal-induced neurotoxicity, protein aggregation, and reactive oxygen species generation in CNS tissue

Some patients benefit from splitting the dose into two injections per week (e.g., Monday/Thursday) to reduce the peak-to-trough variation