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doi: 10.1016/j.jhep.2021.10.013 45

doi: 10.1016/j.scienta.2021.110385 47 QuevalG.NoctorG

Given CHEs multidimensional burden, optimal diagnosis and treatment strategies to control the chronic signs and symptoms of disease are essential (Fig

Using biotin-probe profiling, gene knockout/knock-in models, UPLC-MS metabolomics and computational simulations, the researchers demonstrated that: CD36 binds multiple PROTAC molecules (including SIM1-Me, MZ1 and ARV-110) as well as large-molecule drugs such as rapamycin, navitoclax, birinapant, tubacin and doxorubicin, thereby promoting their cellular uptake and pharmacological activity