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This is especially so in nations in which female smoking rates have not shown a pattern of steady increase in stage II, despite high prevalence among males, most likely due to social or cultural constraints

In addition, quitting can require more than one attempt [4]

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Although the long-term health effects of e-cigarettes are still under exploration, initial concerns include the effect of nicotine on brain development 3 , adverse respiratory symptoms 4 , potential for nicotine addiction 5 , and transitions to cigarette initiation and use 6