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10.1186/s4036001802808 124 MengZ.ZhuB.GaoM.WangG.ZhouH.LuJ.et al (2022)

Polysaccharide fractions Ganoderma atrum polysaccharide (PSG-1) and Ganoderma applanatum polysaccharides (GAP)derived from *Ganoderma lucidum* (tree-leaf reishi)have been demonstrated to ameliorate acrylamide- or cadmium-induced nephrotoxicity, primarily through suppression of the oxidative DNA damage marker 8-hydroxy-2-deoxyguanosine (8-OHdG), restoration of endogenous antioxidant enzyme function, and correction of dysregulated metabolic pathways ( Further investigations have revealed that increased glucose levels can cause advanced glycation end-products (AGEs) to bind to their receptors (RAGE), which in turn activates NOX to produce reactive oxygen species (ROS)

Tri-Fortify contains .032g per serving of natural sugar

Hypoxia up-regulates expression of hemoglobin in alveolar epithelial cells