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10.1111/j.1365-2222.2010.03684.x

However, it is important to note that there is insufficient data on safety or side effects in humans, and these peptides remain strictly for laboratory research purposes only

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Notably, obesity and joint injury remain the most prominent modifiable risk factors, whereas age, sex, and genetic predisposition are considered non-modifiable contributors (Figure 2) (Nedunchezhiyan et al., 2022