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In hippocampal neuron cultures, Dihexa was reported to induce spinogenesis and synaptogenesis at picomolar concentrations the basis for the widely-cited seven orders of magnitude more potent than BDNF potency figure

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Hed found in the lungs, the peptide directly activates ENaC-alpha, a subunit of natural body channels which mediate sodium uptake and play a role in fluid movement, Lucas explains, noting fluids natural propensity to follow sodium, or salt

Additionally, it stabilizes the gut lining by activating the focal adhesion kinase pathway (FAK), protecting the mucosal barrier from toxins and stress