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Copper is essential for many enzymes responsible for: Collagen and elastin production (for firm, resilient skin and connective tissue) Antioxidant protection, including enzymes like superoxide dismutase (SOD) Cellular energy metabolism and repair processes GHK-Cu therefore helps regulate both the breakdown of damaged tissue and the formation of healthy new tissue, giving it importance in research on wound healing, anti-aging, hair growth, and even gene expression regulation

Knee arthroplasty was used as the severity indicator for OA development

Data were independently extracted by two reviewers into a standardized spreadsheet, and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model

and 11 a.m.-6 p.m