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They defined hyperhomocysteinemia as severe for concentrations higher than 100 mol/L, intermediate for concentrations between 30 and 100 mol/L, and moderate for concentrations of 15 to 30 mol/L, and a reference total plasma homocysteine range as 5 to 15 mol/L (mean, 10 mol/L)

Indeed, the stronger relationship between elevated circulating homocysteine levels and atherothrombotic disease observed in retrospective case-controlled studies than in prospective studies might be explained by the younger average age of subjects sustaining a coronary event in retrospective studies (in the positive study by Wald et al (1998), see the age comparison between retrospective and prospective studies)

There may be a connection between the development of these connected illnesses and shared genetic susceptibilities as well as lifestyle factors

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