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When reduced glutathione performs this neutralization reaction with ROS, reduced glutathione itself becomes oxidized, which yields the oxidized form of glutathione known as GSSG

Conformational study of GSH and GSSG using constant-pH molecular dynamics simulations

Another glutaminase inhibitor, JHU-083, extensively inhibits Gln-metabolizing enzymes and increases the concentrations of Gln and glucose in the TME by inhibiting glycolysis, relieving the hypoxic state

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