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Statins inhibit the HMGCR (rate-limiting enzyme) activity in early stages of mevalonate pathway and then indirectly affect a number of intermediate products, including non-sterol isoprenoids (coenzyme Q10, dolichol etc.), which can result in impaired functions of body organs

This is especially relevant for those with known MTHFR mutations (18)

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With conventional therapeutic agents, certain cancer cells can evade cell death, leading to the persistence of a tumor mass containing tolerant or persister cells