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In PD pathology, ASC specks are considered hallmarks of pyroptosis, as their expression has been observed in peripheral blood mononuclear cells, and this exacerbation is sufficient to enhance NLRP3 inflammasome formation (Fan et al., 2020

NASH is the progressive form of NAFLD, characterized by hepatocyte death and hepatic inflammation

Its also involved in synthesizing fatty acids and myelin via its role as a co-enzyme (2)

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