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Lean, metabolically healthy profiles use roughly 0.3 to 0.5 mg because exposure and heart-rate sensitivity are higher at the same nominal dose. These sub-1 mg ranges are modeled rather than outcome-tested

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We speculate that PUFAs and iron are specifically absorbed in the small intestine 32,33,44 , which could be one explanation for small intestinal disease localization and a requirement for GPX4 activity in the small intestine