The dissociation constant is usually written as a quotient of the equilibrium concentrations (in mol/L), denoted by (HA), (A - ) and (H 3 O + ) K a = (A - )*(H 3 O + ) / (HA)*(H 2 O) In all, but the most concentrated, aqueous solutions of an acid the concentration of water can be taken as constant and can be ignored
The unique pharmacological profile of tirzepatide allows a greater engagement of the GIP receptor, mimicking the actions of native GIP, compared to the GLP-1 receptor, where it activates biased downstream signals favoring cAMP generation over beta-arrestin recruitment, resulting in reduced receptor internalization and degradation 2
While similar to Wegovy in how it works for weight loss, its dosed differently
Such improvement promotes lipogenesis in fat (recall that IGF-1 could maintain cytokine homeostasisanti-inflammatory effects-, and thus protection from mild inflammation as a consequence of obesity)