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Journal of Biomaterials Science, Polymer Edition, 19(8), 969-988

DHA and other polyunsaturated fatty acids activate the redox-sensitive Nrf2 transcription factor to promote glutathione synthesis through expression of Gclc (encoding the rate-limiting enzyme in glutathione synthesis), as well as other genes involved in maintenance of cellular redox state (Fig

Starting Concentration and Gradual Introduction Many dermatologists recommend starting with lower concentrations, under 0.5%, and gradually increasing to higher strengths as your skin acclimates