In vitro experiments confirmed that A 25-35 treatment significantly inhibited the activation of the NRF2/SLC7A11/GPX4 signaling pathway in HT22 cells, upregulated the expression of Fe 2+ , TFR1, ACSL4, MDA, and GSSG, and decreased the expression of FTH1, SOD, and GSH, as well as the GSH/GSSG ratio, resulting in dysregulated neuronal iron metabolism, impaired amino acid antioxidant systems, mitochondrial dysfunction, and ferroptosis, which ultimately promoted neuronal injury
R., Levine, J., Gershon, S., Mallinger, A
Its stability in the digestive environment also allows it to be effective when taken orally, making it well-suited for gut-focused protocols
Conclusions: Mel and Dex are both safe for sleep induction prior to EEG recording in children