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3.6 Epithelialmesenchymal transition EMT is a complex biological process in which renal tubular epithelial cells lose their characteristic features and acquire mesenchymal-like properties ( In DKD, in response to severe or persistent inflammation, TECs undergo EMT through various signaling pathways, such as TGF-, Wnt/-catenin, PI3K/Akt, JAK/STAT, and Notch pathways ( Nevertheless, the precise detection of EMT in renal tissues remains challenging, and the development of effective anti-EMT therapies has been impeded for a long time