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Unlike GLP-1 agonists such as semaglutide or tirzepatide, which work primarily through appetite suppression, AOD-9604 directly enhances fat metabolism at the cellular level through beta-3 adrenergic receptor modulation

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This jives with evidence suggesting that nNOS inhibition is a mediator of anxiolytic and mood-improving effects of medications used to treat both PTSD and other anxiety/mood disorders (Zhu et al., 2023)

Data Collection All patients had been sedated by continuous infusion of propofol and opioid, and were fully adapted to volume-controlled mode with a tidal volume (Vt) set at 7-9 ml/kg of ideal body weight, and a positive end-expiratory pressure (PEEP) of 5-15 cmH 2 O