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This triggers the activation of the adaptive immune system, where autoreactive T lymphocytes exacerbate melanocyte damage in vitiligo-affected skin through the secretion of pro-inflammatory cytokines (Fig

The effect of Sal A on transsulfuration pathway and this pathway-dependent GSH synthesis found in this study provides a new sight into the antioxidant effect of Sal A besides its catechol structures and is suggested to be one of the multiple mechanisms accounting for the potential beneficial effects of Sal A