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1, 5 Pharmacological therapies There is some evidence to support the use of acetylcholinesterase-inhibitors, and some other antidementia drugs 1- 3 Non-pharmacological therapies Cognitive training routines have been investigated to improve cognition in PD 1 Some evidence suggests that physical exercise can improve non-motor symptoms, including cognition in patients with PD 1 Again, some studies have suggested deep brain stimulation could be effective in patients with PD and cognitive symptoms 1

Supplementary material The Supplementary material for this article can be found online at: References 1 AbeF

For quantification, samples are imaged with an LSM880 laser scanning confocal microscope (Zeiss) or an Operetta high-content imager (Perkin Elmer)

Subcutaneous injection into abdominal fat or near the site of injury (as commonly practiced by self-experimenters) is the most reported approach, but this is not a clinical protocol