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Example 114: Combination use of PI3K-6 inhibitors and agents that inhibit IgE production or activity [00702] The compounds as provided herein can present synergistic or additive efficacy when administered in combination with agents that inhibit IgE production or activity

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Conversely, the kynurenine/tryptophan ratio, which serves as an index of IDO activity, increased solely in patients with severe MDD, i.e., MDD with psychotic features [135]