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And under the Family Smoking Prevention and Tobacco Control Act, the 2009 law that charged the FDA with regulating tobacco products, manufacturers have to persuade the agency that a modified-risk claim is not only accurate but will "benefit the health of the population as a whole, taking into account both users of tobacco products and persons who do not currently use tobacco products." That "population as a whole" standard means it's not enough to demonstrate that a product is significantly less dangerous than cigarettes

At present, it is unclear how cigarette smoking leads to MAO inhibition, but preclinical studies in rodents show that MAO inhibition increases nicotine self-administration, especially at low doses of nicotine

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