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However, weight loss from calorie restriction is accompanied by metabolic adaptation, a decrease in metabolic rate below that predicted from the body weight (BW) and composition 2,3,4,5
Severe gastrointestinal conditions: Those with delayed gastric emptying, gastroparesis, or chronic GI dysmotility may experience exacerbated symptoms due to the drugs action on gastric motility
Hamed MA, Wasinger V, Wang Q, Graham P, Malouf D, Bucci J, et al