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Functional experiments further showed that overexpression of PAX5, one of the genes upregulated in T2D, led to reduced insulin secretion, suppression of mitochondrial respiration, and disruption of energy balance through regulation of downstream genes such as BARX1, NEFL, PCOLCE2, and SFRP1 ( via an alternative SQSTM1 p62-mediated pathway, the levels of which are also elevated (Marques et al., 2022)

A., Alzahrani, A

Consequently, cysteine availability and the resulting GCS activity are both pivotal for GSH re-synthesis and therefore provide an indication of the models potential to recover GSH levels 21

Ninomiya T, Kiyohara Y, Kubo M, Yonemoto K, Tanizaki Y, Doi Y, Hirakata H, Iida M