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Digital promotion remains a major challenge The evaluation further highlighted the changing nature of advertising and promotion

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Nicotine, as an agonist of nicotinic acetylcholine receptor (nAChR), can act on the vagal pathway and its collateral branch and the anti-inflammatory pathway mediated by the nicotinic acetylcholine receptor, which is the main mechanism of nicotines pharmacological activity (Onor et al., 2017)