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The regulation of core body temperature by citrulline is mediated through its effects on the secretion of inflammatory cytokines, initiating a neuroendocrine immunoregulatory cascade (Uyanga et al., 2022)

Using the FDA's body-surface-area conversion, a 10 mcg/kg rat dose maps to roughly 1.6 mcg/kg in a human, but most practitioners use higher doses based on clinical experience

Healthy tendons, ligaments, and fascia are essential for progressive overload training, and the peptide ability to maintain and repair these structures may prevent the connective tissue injuries that commonly sideline athletes

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